What is VIP?
VIP is a C-terminally amidated 28-amino-acid peptide. It acts via the VPAC1 and VPAC2 receptors and occurs in the nervous system, gut, lung and immune cells.
More data in the lexicon entry on VIP.
State of research
VIP was isolated from pig intestine in 1970 by Sami Said and Viktor Mutt, first for its vasodilating effect. Later it turned out to occur throughout the nervous system, acting through the VPAC1 and VPAC2 receptors.
Today VIP is studied in very different fields: as a timing signal of the circadian clock in the suprachiasmatic nucleus, in bronchodilation, intestinal secretion and as an anti-inflammatory signal for T cells and macrophages. Clinically it was tested as aviptadil, among others in lung disease and acute respiratory failure. Its short half-life in blood of a few minutes is a key challenge.
Status and quality
VIP was tested clinically as aviptadil; there is no general EU approval as a medicine. Peptidkauf sells VIP solely as a research reagent for laboratory and in-vitro use and gives no dosing or application advice.
An independent laboratory tests every batch for purity (HPLC), identity and measured content before it goes on sale; the reports and their verification keys are in the lab report archive. The material ships as lyophilised powder in a glass vial; storage and laboratory handling are covered under storage & handling.
Related products and articles
Related neuropeptides: oxytocin, selank. More immune peptides: thymosin alpha-1, KPV.
