What is Dihexa Capsules?
Dihexa (N-hexanoyl-Tyr-Ile-(6)-aminohexanoic amide) is a peptidomimetic from angiotensin IV research. It binds hepatocyte growth factor and promotes its dimerisation. In capsule form the substance comes in a constant amount per capsule, which makes standardised test series without reconstitution easier.
More data in the lexicon entry on Dihexa.
State of research
Dihexa was developed at Washington State University by the group of Joseph Harding and John Wright. The starting point was angiotensin IV, a peptide that influenced memory in animal models but is rapidly degraded in the body. Dihexa is a much shorter, stable variant.
Two papers shape the literature: McCoy et al. (2013) reported that dihexa crosses the blood-brain barrier, is orally active and reduced memory deficits in rat models. Benoist et al. (2014) showed that it binds HGF and enhances activation of the c-Met receptor, which stimulated new synapse formation in cell culture. Long-term safety is an open question, since the HGF/c-Met pathway also promotes cell growth.
Status and quality
Dihexa is not approved as a medicine. Peptidkauf sells Dihexa Capsules solely as a research reagent for laboratory and in-vitro use and gives no dosing or application advice.
An independent laboratory tests every batch for identity and content before it goes on sale; the reports and their verification keys are in the lab report archive. Store the capsules dry, protected from light and at room temperature; no reconstitution is needed.
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