Peptide lexicon
Dihexa
Orally available angiotensin IV analogue that potentiates HGF/c-Met signalling and is studied in synapse research.
| Substance class | Peptide |
|---|---|
| Sequence | N-Hexanoyl-Tyr-Ile-(6)-aminohexanoic amide |
| Synonyms | PNB-0408, N-Hexanoic-Tyr-Ile-(6)-Aminohexanoic Amide |
Structure
Dihexa (N-hexanoyl-Tyr-Ile-(6)-aminohexanoic amide) is a peptidomimetic from angiotensin IV research. It binds hepatocyte growth factor and promotes its dimerisation.
State of research
Animal studies describe the formation of new synapses (spinogenesis) and improvements in memory models; there are no human data.
Status
Dihexa is not approved as a medicinal product.
Literature
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future DirectionsJ Am Acad Orthop Surg Glob Res Rev, 2026 · PMID 41490200 · DOI 10.5435/JAAOSGlobal-D-25-00236
- Hepatocyte Growth Factor and Macrophage-stimulating Protein "Hinge" Analogs to Treat Pancreatic CancerCurr Cancer Drug Targets, 2019 · PMID 30914029 · DOI 10.2174/1568009619666190326130008
- The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's DiseaseJ Alzheimers Dis, 2015 · PMID 25649658 · DOI 10.3233/JAD-142814
- Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studiesNeurosci Biobehav Rev, 2018 · PMID 29733881 · DOI 10.1016/j.neubiorev.2018.05.005
- The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseasesProg Neurobiol, 2015 · PMID 25455861 · DOI 10.1016/j.pneurobio.2014.11.004
