Peptide lexicon
BPC-157
Synthetic 15-amino-acid peptide from a gastric juice protein; one of the most studied peptides in preclinical regeneration models.
| Substance class | Peptide |
|---|---|
| Sequence | GEPPPGKPADDAGLV |
| CAS number | 137525-51-0 |
| Molecular formula | C₆₂H₉₈N₁₆O₂₂ |
| Molar mass | 1,419.5 g/mol |
| Synonyms | Body Protection Compound 157, Bepecin |
| PubChem | CID 9941957 |
Structure and origin
BPC-157 (Body Protection Compound 157) is a linear pentadecapeptide with the sequence GEPPPGKPADDAGLV. It is derived from a fragment of a protein described in human gastric juice and is comparatively stable in aqueous and acidic solution.
Research focus
The literature consists mainly of cell culture and animal studies, many of them from a single research group in Zagreb. Topics include angiogenesis (including VEGFR2 signalling), the nitric oxide axis, fibroblast migration and models of tendon, muscle, bone and mucosal injury.
Status
Controlled human studies are very limited, and there is no marketing authorisation in the EU. Since 2022 the World Anti-Doping Agency lists BPC-157 under category S0 (non-approved substances).
Literature
- Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent ReviewPharmaceuticals (Basel), 2025 · PMID 40005999 · DOI 10.3390/ph18020185
- Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healingCell Tissue Res, 2019 · PMID 30915550 · DOI 10.1007/s00441-019-03016-8
- Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic ReviewHSS J, 2025 · PMID 40756949 · DOI 10.1177/15563316251355551
- Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats-A ReviewPharmaceuticals (Basel), 2024 · PMID 39204186 · DOI 10.3390/ph17081081
- Stable Gastric Pentadecapeptide BPC 157 and Wound HealingFront Pharmacol, 2021 · PMID 34267654 · DOI 10.3389/fphar.2021.627533
