Peptide lexicon
N-Acetyl Semax Amidat
N-terminally acetylated, C-terminally amidated form of Semax with higher stability against peptidases.
| Substance class | Peptide |
|---|---|
| Sequence | Ac-MEHFPGP-NH2 |
| Synonyms | NA-Semax-NH2 |
Structure
N-Acetyl Semax Amidate has the Semax sequence (MEHFPGP) with an acetyl group at the N-terminus and an amide at the C-terminus. Both terminal modifications slow degradation by exopeptidases.
State of research
Research questions follow Semax: BDNF expression, neuroprotection in ischaemia models and melanocortin-family signalling. Studies specifically on the acetylated form are rare.
Status
N-Acetyl Semax is not approved as a medicinal product.
Literature
- [A comparative chemoreactome analysis of mexidol]Zh Nevrol Psikhiatr Im S S Korsakova, 2017 · PMID 28514338 · DOI 10.17116/jnevro20171171275-84
- Effects of behaviorally active ACTH (4-10) analogue - Semax on rat basal forebrain cholinergic neuronsRestor Neurol Neurosci, 2008 · PMID 18431004
- Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological propertiesJ Inorg Biochem, 2016 · PMID 27586814 · DOI 10.1016/j.jinorgbio.2016.08.013
- [The nootropic correction of disorders in learning and memory processes induced by extreme exposures]Eksp Klin Farmakol, 1996 · PMID 8974577
- Stability of Semax acetyl to proteolysis in various biological mediaDokl Biol Sci, 2013 · PMID 23652441 · DOI 10.1134/S0012496613020166
