Peptide lexicon
Methylenblau
Phenothiazine dye and redox cycler that can transfer electrons in the mitochondrial respiratory chain.
| Substance class | Small Molecule |
|---|---|
| CAS number | 61-73-4 |
| Molecular formula | C₁₆H₁₈ClN₃S |
| Molar mass | 319.9 g/mol |
| Synonyms | Methylthioniniumchlorid, CI 52015 |
| PubChem | CID 6099 |
Structure
Methylene blue (methylthioninium chloride, C₁₆H₁₈ClN₃S) switches between the oxidised blue form and reduced, colourless leucomethylene blue. This redox behaviour makes it a classic laboratory dye and electron carrier.
State of research
Research covers electron transfer that bypasses complexes I–IV, oxygen utilisation, monoamine oxidase inhibition and models of neurodegenerative disease; in microscopy it is used as a stain.
Status
Methylene blue is approved as a medicinal substance for specific indications. The material offered here is a research reagent.
Literature
- Methylene blue in sepsis and septic shock: a systematic review and meta-analysisFront Med (Lausanne), 2024 · PMID 38698779 · DOI 10.3389/fmed.2024.1366062
- Methylene Blue in Septic Shock: A Systematic Review and Meta-AnalysisCrit Care Explor, 2024 · PMID 38904978 · DOI 10.1097/CCE.0000000000001110
- Methylene Blue: An Antidote for Methemoglobinemia and BeyondPediatr Emerg Care, 2021 · PMID 34463662 · DOI 10.1097/PEC.0000000000002526
- Vasoactive-Inotropic Score: Evolution, Clinical Utility, and PitfallsJ Cardiothorac Vasc Anesth, 2021 · PMID 33069558 · DOI 10.1053/j.jvca.2020.09.117
- Management of Refractory Anaphylaxis: An Overview of Current GuidelinesClin Exp Allergy, 2024 · PMID 38866583 · DOI 10.1111/cea.14514
