Peptide lexicon
Ipamorelin
Selective agonist of the ghrelin receptor (GHS-R1a) from the group of pentapeptide GH secretagogues.
| Substance class | Peptide |
|---|---|
| Sequence | Aib-His-D-2Nal-D-Phe-Lys-NH2 |
| CAS number | 170851-70-4 |
| Molecular formula | C₃₈H₄₉N₉O₅ |
| Molar mass | 711.9 g/mol |
| Synonyms | NNC 26-0161 |
| PubChem | CID 9831659 |
Structure
Ipamorelin is a pentapeptide (Aib-His-D-2Nal-D-Phe-Lys-NH₂) containing non-proteinogenic building blocks that increase stability against peptidases. It was described in the 1990s as a selective GH secretagogue.
Research focus
In animal models ipamorelin triggers dose-dependent growth hormone release without – unlike GHRP-6 or hexarelin – markedly raising ACTH or cortisol. Further studies address effects on gastrointestinal motility.
Status
There is no marketing authorisation. WADA lists GH secretagogues in category S2.
Literature
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic PerformanceSports Med, 2026 · PMID 41966639 · DOI 10.1007/s40279-026-02437-0
- Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine PhysiciansAm J Sports Med, 2026 · PMID 41476424 · DOI 10.1177/03635465251357593
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future DirectionsJ Am Acad Orthop Surg Glob Res Rev, 2026 · PMID 41490200 · DOI 10.5435/JAAOSGlobal-D-25-00236
- Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future PerspectivesInt J Mol Sci, 2026 · PMID 42123471 · DOI 10.3390/ijms27093890
- A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical reviewJ Sports Med Phys Fitness, 2026 · PMID 41880199 · DOI 10.23736/S0022-4707.26.17773-1
