Peptide lexicon
Alarelin
GnRH agonist with D-alanine at position 6 and an ethylamide C-terminus.
| Substance class | Peptide |
|---|---|
| Sequence | pE-HWSY-D-Ala-LRP-NHEt |
| Synonyms | GnRH-Analogon |
Structure
Alarelin is a nonapeptide GnRH analogue (pGlu-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt). The modifications increase stability and receptor affinity compared with the native hormone.
State of research
Research covers stimulation and — with continuous exposure — desensitisation of the pituitary, and applications in animal reproductive biology.
Status
Alarelin is not approved as a human medicinal product in the EU.
Literature
- Pharmacogenomic analysis of alarelin acetate-induced hepatotoxicity: a case report and literature reviewFront Med (Lausanne), 2025 · PMID 41090118 · DOI 10.3389/fmed.2025.1634101
- Liquid chromatography tandem mass spectrometry with triple stage fragmentation for highly selective analysis and pharmacokinetics of alarelin in rat plasmaJ Sep Sci, 2019 · PMID 31257725 · DOI 10.1002/jssc.201900359
- Alarelin active immunization influences expression levels of GnRHR, FSHR and LHR proteins in the ovary and enhances follicular development in ewesAnim Sci J, 2013 · PMID 23607296 · DOI 10.1111/asj.12030
- Induction of Spermiation in Sterlet Acipenser ruthenus by PLGA Microparticle Delivery with Sustained Alarelin ReleaseAnimals (Basel), 2021 · PMID 34828035 · DOI 10.3390/ani11113305
- The direct effects of gonadotropin-releasing hormone on proliferation of granulosa cells and development of follicles in gooseBr Poult Sci, 2020 · PMID 32019334 · DOI 10.1080/00071668.2020.1724877
