Peptide lexicon
TRH (Protirelin)
Thyrotropin-releasing hormone, a hypothalamic tripeptide (protirelin).
| Substance class | Peptide |
|---|---|
| Sequence | pE-H-P-NH2 |
| CAS number | 24305-27-9 |
| Molecular formula | C₁₆H₂₂N₆O₄ |
| Molar mass | 362.38 g/mol |
| Synonyms | Protirelin, Thyroliberin |
| PubChem | CID 638678 |
Structure
TRH consists of pyroglutamic acid, histidine and prolinamide (pGlu-His-Pro-NH₂). It stimulates the release of TSH and prolactin from the pituitary.
State of research
Research covers the thyroid axis, central effects on arousal and mood, and TRH analogues with higher stability.
Status
Protirelin is approved as a diagnostic agent. The material offered here is a research reagent.
Literature
- Thyroid hormone regulation of metabolismPhysiol Rev, 2014 · PMID 24692351 · DOI 10.1152/physrev.00030.2013
- Thyroid function in critically ill patientsLancet Diabetes Endocrinol, 2015 · PMID 26071885 · DOI 10.1016/S2213-8587(15)00225-9
- Hypothalamus-Pituitary-Thyroid AxisCompr Physiol, 2016 · PMID 27347897 · DOI 10.1002/cphy.c150027
- Hypothyroidism: etiology, diagnosis, and managementMed Clin North Am, 2012 · PMID 22443971 · DOI 10.1016/j.mcna.2012.01.005
- Diagnosis of hypoprolactinemiaRev Endocr Metab Disord, 2024 · PMID 39037546 · DOI 10.1007/s11154-024-09896-8
