Peptide lexicon
Matrixyl (Palmitoyl-Pentapeptid-4)
Palmitoyl pentapeptide-4 (Pal-KTTKS), a matrikine analogue from procollagen I widely used in cosmetic research.
| Substance class | Peptide |
|---|---|
| Sequence | Pal-KTTKS |
| Synonyms | Palmitoyl Pentapeptide-4, Pal-KTTKS |
Structure
Matrixyl consists of the pentapeptide Lys-Thr-Thr-Lys-Ser, a segment of type I procollagen, with palmitic acid on the N-terminus for better skin penetration.
State of research
Research covers the synthesis of collagen I and III and fibronectin in fibroblasts and effects in skin models.
Status
Matrixyl is a common cosmetic ingredient; it is not approved as a medicinal product.
Literature
- Application of genomics to breakthroughs in the cosmetic treatment of skin ageing and discolorationBr J Dermatol, 2012 · PMID 22670614 · DOI 10.1111/j.1365-2133.2012.10960.x
- Topical palmitoyl pentapeptide provides improvement in photoaged human facial skinInt J Cosmet Sci, 2005 · PMID 18492182 · DOI 10.1111/j.1467-2494.2005.00261.x
- Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing ActivitiesMicrobiol Spectr, 2022 · PMID 35950860 · DOI 10.1128/spectrum.02291-21
- Effect of Palmitoyl-Pentapeptide (Pal-KTTKS) on Wound Contractile Process in Relation with Connective Tissue Growth Factor and α-Smooth Muscle Actin ExpressionTissue Eng Regen Med, 2017 · PMID 30603464 · DOI 10.1007/s13770-016-0017-y
- The Reparative Effect of Dendrobium officinale Protocorms against Photodamage Caused by UV-Irradiation in Hairless MiceBiol Pharm Bull, 2019 · PMID 31061314 · DOI 10.1248/bpb.b18-00901
