Peptide lexicon
KPV
Tripeptide Lys-Pro-Val, the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH 11–13), studied in inflammation models.
| Substance class | Peptide |
|---|---|
| Sequence | KPV |
| CAS number | 67727-97-3 |
| Molecular formula | C₁₆H₃₀N₄O₄ |
| Molar mass | 342.43 g/mol |
| Synonyms | α-MSH(11–13), Lys-Pro-Val |
| PubChem | CID 125672 |
Structure
KPV corresponds to amino acids 11–13 of α-MSH. Unlike the full hormone it shows little melanotropic activity in studies but retains anti-inflammatory properties.
Research focus
Studies examine inhibition of NF-κB signalling and pro-inflammatory cytokines, including models of inflammatory bowel disease and skin inflammation. Part of the work addresses uptake via the peptide transporter PepT1 and nanoparticle carrier systems.
Status
The evidence is preclinical; there is no marketing authorisation.
Literature
- A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical reviewJ Sports Med Phys Fitness, 2026 · PMID 41880199 · DOI 10.23736/S0022-4707.26.17773-1
- The neuroimmunomodulatory peptide alpha-MSHAnn N Y Acad Sci, 2000 · PMID 11268347 · DOI 10.1111/j.1749-6632.2000.tb05386.x
- Host defense peptides as a new drug lead to a strategy for inflammatory bowel diseaseDrug Discov Today, 2025 · PMID 41241376 · DOI 10.1016/j.drudis.2025.104535
- The neuropeptide alpha-MSH in host defenseAnn N Y Acad Sci, 2000 · PMID 11268348 · DOI 10.1111/j.1749-6632.2000.tb05387.x
- New insights into the functions of alpha-MSH and related peptides in the immune systemAnn N Y Acad Sci, 2003 · PMID 12851308 · DOI 10.1111/j.1749-6632.2003.tb03172.x
