Peptide lexicon
Kisspeptin-10
Kisspeptin-10, the C-terminal decapeptide of the kisspeptins and ligand of the KISS1R (GPR54) receptor, a key signal of the gonadotropic axis.
| Substance class | Peptide |
|---|---|
| Sequence | YNWNSFGLRF-NH2 |
| CAS number | 374675-21-5 |
| Molecular formula | C₆₃H₈₃N₁₇O₁₄ |
| Molar mass | 1,302.4 g/mol |
| Synonyms | Metastin(45–54), KP-10 |
| PubChem | CID 25240297 |
Structure
Kisspeptins derive from the precursor protein of the KISS1 gene. Kisspeptin-10 (YNWNSFGLRF-NH₂) is the shortest fully active fragment.
Research focus
Via KISS1R, kisspeptin controls GnRH release in the hypothalamus and thereby puberty and the hypothalamic–pituitary–gonadal axis. Effects on metastasis (original name: metastin) and metabolism are also studied.
Status
No marketing authorisation in the EU; kisspeptin is used as a tool in clinical research.
Literature
- History of Puberty: Normal and PrecociousHorm Res Paediatr, 2022 · PMID 36446322 · DOI 10.1159/000526464
- Stress, kisspeptin, and functional hypothalamic amenorrheaCurr Opin Pharmacol, 2022 · PMID 36103784 · DOI 10.1016/j.coph.2022.102288
- Hypothalamo-Pituitary axis and pubertyMol Cell Endocrinol, 2021 · PMID 33271219 · DOI 10.1016/j.mce.2020.111094
- Contrôle de l’axe gonadotrope : nouveaux aspects physiologiques et thérapeutiques: Control of the gonadotrope axis: new physiologic and therapeutic aspectsAnn Endocrinol (Paris), 2017 · PMID 29157487 · DOI 10.1016/S0003-4266(17)30923-X
- Central precocious puberty: From genetics to treatmentBest Pract Res Clin Endocrinol Metab, 2018 · PMID 30086862 · DOI 10.1016/j.beem.2018.05.008
