Peptide lexicon
Cardiogen
Tetrapeptide Ala-Glu-Asp-Arg from the group of short peptide bioregulators, studied in models of heart muscle tissue.
| Substance class | Peptide |
|---|---|
| Sequence | AEDR |
| Molecular formula | C₁₈H₃₁N₇O₉ |
| Molar mass | 489.47 g/mol |
| Synonyms | Ala-Glu-Asp-Arg |
Structure
Cardiogen is the tetrapeptide AEDR (C₁₈H₃₁N₇O₉, 489.5 g/mol, calculated from the sequence). It belongs to the synthetic short peptides of the St Petersburg Institute of Bioregulation and Gerontology.
Research focus
Publications describe effects on proliferation and gene expression in fibroblast and cardiomyocyte cultures and in animal models. An interaction with DNA and chromatin is discussed as the mode of action.
Status
The literature comes mostly from one research group.
Literature
- [Extracorporeal membrane oxygenation in intensive care unit]Orv Hetil, 2021 · PMID 33714941 · DOI 10.1556/650.2021.32033
- Rubidium Chloride Rb 822006 · PMID 29999675
- Rubidium-82 generator yield and efficiency for PET perfusion imaging: Comparison of two clinical systemsJ Nucl Cardiol, 2020 · PMID 32436115 · DOI 10.1007/s12350-020-02200-6
- Limitations of Rb-82 weight-adjusted dosing accuracy at low dosesJ Nucl Cardiol, 2017 · PMID 27184903 · DOI 10.1007/s12350-016-0531-2
- [The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats]Adv Gerontol, 2009 · PMID 20210190
