Peptide lexicon
Adipotide
Peptidomimetic combining a prohibitin-binding targeting peptide with a pro-apoptotic sequence, developed to study the blood vessels of adipose tissue.
| Substance class | Peptide |
|---|---|
| CAS number | 859216-15-2 |
| Molecular formula | C₁₁₁H₂₀₆N₃₆O₂₈S₂ |
| Molar mass | 2,557.2 g/mol |
| Synonyms | Prohibitin-TP01, FTPP |
| PubChem | CID 163360068 |
Structure
Adipotide (also FTPP or prohibitin-TP01) links a cyclic targeting sequence (CKGGRAKDC), which binds prohibitin on endothelial cells of white adipose tissue, to the membrane-disrupting sequence D(KLAKLAK)₂.
Research focus
Rodent and primate models studied how targeted damage to adipose vasculature changes fat mass and metabolic parameters. Effects on kidney function were also described.
Status
The data are preclinical; there is no authorisation.
Literature
- A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeysSci Transl Med, 2011 · PMID 22072637 · DOI 10.1126/scitranslmed.3002621
- A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medicationJ Control Release, 2013 · PMID 23871959 · DOI 10.1016/j.jconrel.2013.07.013
- Comment on "a peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys"Sci Transl Med, 2012 · PMID 22539771 · DOI 10.1126/scitranslmed.3003760
- Prohibitin: targeting peptide coupled to ovarian cancer, luteinization and TGF-β pathwaysJ Ovarian Res, 2017 · PMID 28427435 · DOI 10.1186/s13048-017-0325-4
- Fatty Liver/Adipose Tissue Dual-Targeting Nanoparticles with Heme Oxygenase-1 Inducer for Amelioration of Obesity, Obesity-Induced Type 2 Diabetes, and SteatohepatitisAdv Sci (Weinh), 2022 · PMID 36209391 · DOI 10.1002/advs.202203286
