Peptide lexicon
PE-22-28
Shortened analogue (7 amino acids) of the peptide spadin, which inhibits the potassium channel TREK-1; subject of basic neurobiological research.
| Substance class | Peptide |
|---|---|
| Sequence | GVSWGLR |
| CAS number | 1801959-12-5 |
| Molecular formula | C₃₅H₅₅N₁₁O₉ |
| Molar mass | 773.9 g/mol |
| Synonyms | Spadin-Analogon |
| PubChem | CID 165437303 |
Structure and origin
Spadin is a peptide from the propeptide of the sortilin receptor. PE-22-28 (GVSWGLR) corresponds to a short, more stable section of it.
Research focus
Animal models study how blocking the TREK-1 channel affects neurogenesis and neuronal plasticity. The evidence is limited to a small number of preclinical studies.
Status
No marketing authorisation. PE-22-28 is also a component of the neuro blend.
Literature
- Fighting against depression with TREK-1 blockers: Past and future. A focus on spadinPharmacol Ther, 2019 · PMID 30291907 · DOI 10.1016/j.pharmthera.2018.10.003
- Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic conceptBr J Pharmacol, 2015 · PMID 25263033 · DOI 10.1111/bph.12953
- First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptidesNeuropharmacology, 2019 · PMID 31325429 · DOI 10.1016/j.neuropharm.2019.107715
- Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathwayPharmacol Res, 2021 · PMID 33737242 · DOI 10.1016/j.phrs.2021.105539
- Sortilin derived propeptide regulation during adipocyte differentiation and inflammationBiochem Biophys Res Commun, 2017 · PMID 27816451 · DOI 10.1016/j.bbrc.2016.10.139
