Peptide lexicon
LZ1
Short antimicrobial peptide studied in research on skin bacteria and inflammation.
| Substance class | Peptide |
|---|---|
| Synonyms | antimikrobielles Peptid LZ1 |
Structure
LZ1 is a synthetic cationic peptide derived from amphibian cathelicidin sequences that acts against Gram-positive bacteria.
State of research
Published studies cover activity against Propionibacterium (Cutibacterium) acnes, inflammatory markers in skin models and serum stability.
Status
LZ1 is not approved as a medicinal product; data are preclinical.
Literature
- Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activationOncogene, 2019 · PMID 30356139 · DOI 10.1038/s41388-018-0556-x
- In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake CathelicidinToxins (Basel), 2019 · PMID 31262018 · DOI 10.3390/toxins11070379
- A small peptide with therapeutic potential for inflammatory acne vulgarisPLoS One, 2013 · PMID 24013774 · DOI 10.1371/journal.pone.0072923
- Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1)Bioorg Med Chem, 2018 · PMID 29661622 · DOI 10.1016/j.bmc.2018.04.018
- Leucine zipper domain targets cAMP-dependent protein kinase to mammalian BK channelsJ Biol Chem, 2003 · PMID 12509433 · DOI 10.1074/jbc.M211661200
