Peptide lexicon
GHRP-6
Growth hormone releasing hexapeptide, one of the first synthetic ghrelin receptor agonists, described in the 1980s.
| Substance class | Peptide |
|---|---|
| Sequence | His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 |
| CAS number | 87616-84-0 |
| Molecular formula | C₄₆H₅₆N₁₂O₆ |
| Molar mass | 873 g/mol |
| Synonyms | Growth Hormone Releasing Hexapeptide |
| PubChem | CID 4345065 |
Structure
GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂) was developed from enkephalin analogues before the ghrelin receptor was known; research on it contributed substantially to the discovery of GHS-R1a and ghrelin.
Research focus
Besides GH release, studies examine appetite-regulating effects via the ghrelin pathway and cytoprotective effects in heart and liver models.
Status
No marketing authorisation; WADA lists GH secretagogues in category S2.
Literature
- Growth hormone releasing hexapeptide-6 (GHRP-6) test in the diagnosis of GH-deficiencyJ Pediatr Endocrinol Metab, 1996 · PMID 8887178
- Growth hormone-releasing peptidesEur J Endocrinol, 1997 · PMID 9186261 · DOI 10.1530/eje.0.1360445
- Regulation of growth hormone secretion by the growth hormone releasing hexapeptide (GHRP-6)J Pediatr Endocrinol, 1993 · PMID 7920995 · DOI 10.1515/jpem.1993.6.3-4.283
- Physiology of ghrelin and related peptidesDomest Anim Endocrinol, 2005 · PMID 15927771 · DOI 10.1016/j.domaniend.2005.02.033
- Diagnosis of adult GH deficiencyGrowth Horm IGF Res, 2008 · PMID 17766155 · DOI 10.1016/j.ghir.2007.07.004
